beclin - Two Beclin 1binding proteins Atg14L and baraspati Rubicon reciprocally regulate autophagy at different stages Nat Cell Biol 200911385396 doi 101038ncb1846 Google Scholar 29 Sun Q Fan W Chen K Ding X Chen S Zhong Q Identification of Barkor as a mammalian autophagyspecific factor for Beclin 1 and class III Bcl2Beclin 1 complex multiple mechanisms regulating autophagy Beclin1 autophagic regulator and therapeutic target in cancer BECN1 is a gene that encodes Beclin 1 a protein involved in autophagy endocytosis and apoptosis Learn about its aliases disorders pathways products functions expression localization and more BECN1 Wikipedia The Role of Beclin 1Dependent Autophagy in Cancer PMC Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl2interacting protein Subsequent studies have demonstrated that this landmark protein is essential for autophagy By investigating the interaction between Bcl2 and Beclin 1 key molecular mechanisms of mammalian autophagy Beclin 1 Bcl2 and Autophagy PubMed In addition Beclin 1 is a key determining factor as to whether cells undergo autophagy or apoptosis Beclin 1 has been shown to interact via its BH3 domain with antiapoptotic Bcl2 family members This interaction prevents Beclin 1 from assembling the preautophagosomal structure thereby inhibiting autophagy The dual role of Bcl2 and BECLIN1 is a wellestablished regulator of autophagy a process essential for mammalian survival It functions in conjunction with other proteins to form Class III Phosphoinositide 3Kinase PI3K complexes to generate phosphorylated phosphatidylinositol PtdIns lipids essential for not only autop The Beclin 1 function in autophagy and the role of its posttranslational modifications implicated in cancer A A diagram of the macroautophagy pathway highlighting the complexes where sqmi Beclin 1 is involved in B A schematic illustration of the Beclin 1 posttranslational modifications implicated in cancer and its consequences in autophagy C inhibition or D induction Beclin1 is a protein that in humans is encoded by the BECN1 gene 5 6 Beclin1 is a mammalian ortholog of the yeast autophagyrelated gene 6 Atg6 and BEC1 in the C elegans nematode 7 This protein interacts with either BCL2 or PI3k class III playing a critical role in the regulation of both autophagy and cell death The Beclin 1 network regulates autophagy and apoptosis PMC Beclin1 the mammalian ortholog of yeast ATG6 has been wellcharacterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles Beclin1 structure has been identified to contain three identifiable domains including BECLIN1 Protein Structure Function and Regulation PMC Beclin 1 is a novel Bcl2homology BH3 domain only protein 9 The embryonic phenotype of Beclin 1 null mice is even more severe than that of other autophagy genedeficient mice which die in early embryonic development E75 or earlier with defects in proamniotic canal closure 10 Beclin 1 is expressed in many human and murine tissues and BECN1 Gene GeneCards BECN1 Protein BECN1 Antibody BECLIN1 Protein Structure Function and Regulation PubMed Beclin1 is depleted in Alzheimers disease brain following caspase3 cleavage Beclin 1independent autophagy is an important contributor to both the caspasedependent and independent components of neuronal apoptosis and may be considered as an important therapeutic target in neural conditions involving apoptosis 8678 Gene ResultBECN1 beclin 1 ryo human National Center for
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