bnip - Aug 14 2012 BNIP2 was first scambler identified as one of the three interacting partners for the antiapoptotic Bcl2 and viral E1B 19 kDa protein hence named Bcl2 and Nineteen kilodaltonInteracting Protein2 BNIP2 10 However its precise biological functions remained unknown then Bcl2adenovirus E1B 19kDa interacting protein 3 BNIP3 is a proapoptotic BH3only protein of the Bcl2 family Its function in various biological processes was described Although potential involvement of BNIP3 in cancer progression has been A brief overview of BNIP3LNIX receptormediated mitophagy Mar 22 2024 Mitophagy plays an important role in the maintenance of mitochondrial homeostasis and can be categorized into two types ubiquitinmediated and receptormediated pathways During receptormediated Dec 24 2024 BNIP3 BCL2 Interacting Protein 3 is a Protein Coding gene Diseases associated with BNIP3 include Leiomyomatosis and Pancreatic CancerAmong its related pathways are Busulfan Pathway Pharmacodynamics and Photodynamic therapyinduced HIF1 survival signaling BNIP3 BCL2 interacting protein 3 regulates pluripotency by The present review is a summary of the recent literature concerning Bnip3 expression function and regulation along with its implications in mitochondrial dysfunction disorders of mitophagy homeostasis and development of diseases of secondary mitochondrial dysfunction As a member of the Bcl2 f Bnip3 in mitophagy Novel insights and potential therapeutic 12176 Ensembl ENSG00000176171 ENSMUSG00000078566 UniProt Q12983 O55003 RefSeq mRNA NM004052 NM009760 RefSeq protein NP004043 NP033890 Location UCSC Chr 10 13197 13198 Mb Chr 7 13849 13851 Mb PubMed search Wikidata ViewEdit Human ViewEdit Mouse BCL2adenovirus E1B 19 kDa proteininteracting protein 3 is a protein found in humans that is encoded by the BNIP3 gene BNIP3 100043324 Ensembl ENSG00000104765 na UniProt O60238 Q6IBV1 na RefSeq mRNA NM004331 NM001330491 XM036157725 RefSeq protein NP001317420 NP004322 NP0043221 na Location UCSC Chr 8 2638 2651 Mb na PubMed search Wikidata ViewEdit Human ViewEdit Mouse BCL2adenovirus E1B 19 kDa proteininteracting protein 3like is a protein that in humans is encoded by the BNIP3L gene BNIP3LNIXmediated mitophagy molecular mechanisms and BNIP3LNIXmediated mitophagy molecular mechanisms and Jan 9 2009 Bcl2 nineteenkilodalton interacting protein BNIP3 is a BH3only Bcl2 family member whose expression levels increase during stress such as hypoxia through hypoxiainducing factor1dependent Role of BNIP3 and NIX in cell death autophagy and mitophagy BNIP2 Gene GeneCards BNIP2 Protein BNIP2 Antibody Bnip3 in mitophagy Novel insights and potential therapeutic Feb 20 2009 Phylogenomics of lifeordeath switches in multicellular animals Bcl2 BH3Only and BNip families of apoptotic regulators Mol Biol Evol 2005 22 23952416 Article CAS PubMed Google Scholar Please note that our application is currently in readonly mode until the end of today During this time you will not be able to make any changes or updates to your account or data BNIP3 Wikipedia Jul 1 yamaha r1 2020 Bnip3 encoded by the BNIP3 gene at human chromosome 10q263 was first known as NIP3 and considered to belong to the Bcl2 family of cell deathregulating factors which is an atypical BH3 domain only containing members of the Bcl2 family of proteins 1 2 BNIP3 in Lung Cancer To Kill or Rescue PMC Dec 20 2021 Cho B Choi SY Park OH Sun W Geum D Differential expression of BNIP family members of BH3only proteins during the development and after axotomy in the rat Mol Cells 20123360510 Apr 11 2022 Autophagymediated mitochondrial degradation plays pivotal roles in both the acquisition and maintenance of pluripotency but the molecular mechanisms that link autophagymediated mitochondrial Dec 24 2024 This gene is a member of the BCL2adenovirus E1B 19 kdinteracting protein BNIP family It interacts with the E1B 19 kDa protein which protects cells from virallyinduced cell death The encoded protein also interacts with E1B 19 kDalike sequences of BCL2 another apoptotic protector Alternate splicing results in multiple transcript variants Molecular mechanisms of receptormediated mitophagy Receptormediated mitophagy mechanisms are regulated by interactions between outer membrane BNIP3 BNIP3LNIX FUNDC1 BCL2L13 AMBRA1 or inner membrane PHB2 mitochondrial receptors which directly bind LC3GABARAP proteins located on the autophagosomal membrane through the conserved LC3interacting region Mitophagy mediated by BNIP3 and NIX protects against Nature BNIP3L Wikipedia Dec 20 2021 Mitophagy is a highly conserved cellular process that maintains the mitochondrial quantity by eliminating dysfunctional or superfluous mitochondria through autophagy machinery The mitochondrial outer membrane protein BNIP3LNix serves as a mitophagy receptor by recognizing autophagosomes BNIP3L is BNIP3L Gene GeneCards BNI3L Protein BNI3L Antibody Functional plasticity of the BNIP2 and Cdc42GAP Homology BNIP3 Gene GeneCards BNIP3 Protein BNIP3 Antibody Hypoxiainduced autophagy cell death or cell survival Oct 1 2022 The BNIP subfamily plays an important role in cell death during hypoxia and form a major extension of the BCL2 family in the regulation of hypoxiainduced cell death 100 Although the mechanism for hypoxiainduced regulation of BNIP3 has been very well studied and includes a conserved HIF response element within the BNIP3 promoter see below BNIP3 and Nix Atypical regulators of cell fate ScienceDirect Dec 24 2024 Complete information for BNIP3L gene Protein Coding BCL2 Interacting Protein 3 Like including function proteins disorders pathways orthologs and expression bnip This process is mediated by the atypical BH3only proteins the Bcl2E1B 19kDainteracting protein 3 BNIP3BNIP3L NIX that are induced by HIF1 These mitochondrial associated BNIP proteins also mediate mitophagy a metabolic adaptation for survival that is able to control reactive oxygen species ROS production and DNA damage The role of Bcl2 family member BNIP3 arti iclik in cell death and
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