caga - Many strains of Helicobacter pylori produce intrafix an immunogenic high molecular weight protein called cytotoxin associated gene product A CagA and infection with such strains can be detected by a simple serological test for antiCagA antibodies Numerous studies over the past nine years have shown that CagA positive infections are more likely than CagA negative infections to result in The function of the cag PAI in H pyloriassociated disease has been the subject of controversy ever since its discovery in 1993 Clinical studies with different outcomes have been performed to test whether the presence of the cag PAI is connected with peptic ulcer disease or gastric cancer Often these studies were based on PCR amplifications of the cagA gene which was used as a marker for Helicobacter pylori Virulence Factor CytotoxinAssociated Jun 9 2021 Tamoxifen T5648 Sigma was dissolved into corn oil C8267 Sigma at a concentration of 20 mgml overnight at room temperature The floxed cagAtransgenic CAGLSLcagA CAGCreER mice or control littermate CAGLSLcagA mice were intraperitoneally injected with 4 mg tamoxifen40 g body weight at 68 weeks of age for 5 consecutive days The CagA toxin of Helicobacter pylori abundant production CagA cytotoxinassociated antigen A is a major virulence factor for H pylori an oncoprotein that is encoded by the cagA gene Bacterial strains with the cagA gene are associated with the ability to cause ulcers MALT lymphomas and gastric cancer 108 109 The cagA gene codes for a relatively long 1186amino acid protein Helicobacter pylori CagA and Gastric Cancer A Paradigm for The expression of CagA is affected by the specific motif In another study a high level of CagA expression associated with the strainspecific motif downstream of the cagA transcriptional start site the 59 motif was found in some strains but not in others 3040 Molecular anatomy and pathogenic actions of Helicobacter Dec 5 2019 CagA is a 128145kilodalton kDa protein that is composed of a structured Nterminal region and an intrinsically disorderedunstructured Cterminal tail 646566 The Nterminus of CagA which CagA is also known as the first bacterial oncoprotein ranking the H pylorimediated adenocarcinoma as the second most deadly cancer type worldwide Upon cytoplasmic translocation CagA undergoes interacting with numerous proteins in phosphorylation dependent and independent manners within the gastric epithelial cells The cagA gene product CagA is delivered into gastric epithelial cells via the bacterial type IV secretion system Delivered CagA then undergoes tyrosine phosphorylation at the GluPro Chronic infection with Helicobacter pylori cagApositive strains is the strongest risk factor for gastric cancer The CagA proteins produced by different strains of H pylori vary from about 120 to 145 kDa in mass Most H pylori contain a single copy of cagA but some strains contain multiple tandem copies CagA is characterized by a structured Nterminal region and an intrinsically disordered Cterminal region 25 26 The cagAencoded CagA protein varies in size from 130 to 145 kilo Daltons kDa because of structural polymorphism in the carboxyterminal Cterminal region Fig 1 2425 As expected from its name siantan CagA was originally considered to act as a bacterial cytotoxin 26 However subsequent study revealed that the acute cytotoxic activity of H Helicobacter pylori CagA from pathogenic mechanisms to its Mar 12 2014 Helicobacter pylori is a gastric bacterial pathogen that is etiologically linked to human gastric cancer The cytotoxinassociated gene A CagA protein of H pylori which is delivered into gastric epithelial cells via bacterial type IV secretion is an oncoprotein that can induce malignant neoplasms in mammals Jan 30 2023 a 1 CagA forms an effectorsecretion chaperone complex with CagF 3663 near the inner membrane where Cagβ is trapped in the inactive monomeric state by CagZ 2 Binding of CagA triggers the The Role of CagA in the Gastric Biology of Helicobacter pylori Oct 14 2013 CagA is a virulence factor of H pylori that can induce epithelial to mesenchymal transition EMT and promote gastric cancer This review discusses the role of CagA in H pylori infection disease development and vaccine design Molecular anatomy and pathogenic actions of Helicobacter Mechanism of regulation of the Helicobacter pylori Cagβ Based on the presence or absence of the cytotoxinassociated gene A cagA in the bacterial genome H pylori is divided into cagApositive and cagAnegative strainsThe cagA gene encodes the bacterial protein CagA which varies in its size from 130 to 145 kDa due to the amino acid sequence variation in its Cterminal region Covacci et al 1993 Helicobacter pylori Wikipedia Helicobacter pylori CagA elicits BRCAness to induce genome Impact of the Helicobacter pylori Oncoprotein CagA in Gastric The cag Pathogenicity Island Helicobacter pylori NCBI The CagA protein is composed of a structural Nterminal region and an intrinsically disordered Cterminal region The KXnRXR motif is required for CagA to physically associate with the membrane phospholipid phosphatidylserine PS in cells Mar 17 2016 CagA is one of the most studied pathogenicity factors of the bacterial pathogen Helicobacter pylori It is injected into host cells via the H pylori cagType IV secretion system Due to its Feb 21 2024 Helicobacter pylori particularly cytotoxinassociated gene A CagApositive strains plays a key role in the progression of gastric cancer GC Ferroptosis associated with lethal lipid CagA Phosphorylation in Helicobacter pyloriInfected B Cells CagAmediated pathogenesis of Helicobacter pylori PubMed CagA a role at last Gut CagA is one of the most important virulence factors of the human pathogen Helicobacter pylori CagA expression can be associated with the induction of severe gastric disorders such as gastritis ulceration gastric cancer or mucosaassociated Structure and function of Helicobacter pylori CagA the first Jul 14 2016 The CagA protein has been recognized as a marker for the entire cag island and has remarkable functions During infection CagA localizes to the host plasma membrane and undergoes tyrosine phosphorylation This was surprising at the time as the previously published H pylori genome sequences do not encode tyrosine kinases The Helicobacter pylori Cag Type IV Secretion System PMC Molecular anatomy and pathogenic actions of Helicobacter Helicobacter pylori intratekal CagAmediated ether lipid biosynthesis
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