difenoksilat - Diphenoxylate and atropine a medication combination crf 2024 for managing diarrhea present a valuable therapeutic option for healthcare professionals Operating within the antimotility class of drugs diphenoxylate exhibits significant efficacy in addressing both acute and chronic episodes of diarrhea This continuing medical education CME activity centers on elucidating the indications action Lomotil is a combination of two drugs diphenoxylate and atropineIt is used to treat acute diarrhea diarrhea of limited duration Diphenoxylate is a manmade narcotic chemically related to meperidine Like other narcotics diphenoxylate reduces diarrhea by interfering with the propulsion of intestinal contents through the intestines Diphenoxylate C30H32N2O2 CID 13505 PubChem Lomotil Diphenoxylate Atropine Uses Side Effects Cleveland Clinic Diphenoxylate an overview ScienceDirect Topics Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrheaDiphenoxylate is an opioid and acts by slowing intestinal contractions the atropine is present to prevent drug abuse and overdose It should not be given to children due to the risk that they will stop breathing and should not be used in Diphenoxylate Wikipedia In one study in fasting individuals diphenoxylate hydrochloride was well absorbed from the GI tract following oral administration of an alcoholic solution of the drug without atropine sulfatePeak plasma diphenoxylate concentrations occurred about 2 hours following administration of the drug In a crossover bioavailability study of Lomotil tablets and oral solution the bioavailability of the Diphenoxylate and Atropine StatPearls NCBI Bookshelf Diphenoxylate and Atropine Tablets Information Drugscom Atropinediphenoxylate Wikipedia Difenoxin Wikipedia Lomotil is a brand of diphenoxylate and atropine Its a medication that treats diarrhea Diarrhea is loose or watery stool poop You can take this tablet by mouth with a glass of water Difenoxin Motofen codinh R15403 is an opioid drug used often in combination with atropine to treat diarrhea 2 It is the principal metabolite of diphenoxylate 3 4 558 It was first approved in the US in 1978 5 and in 1980 in the former West Germany 6 485 Difenoxin crosses the blood brain barrier and induces some euphoria it is often sold with or administered with atropine to Drugscom provides accurate and independent information on more than 24000 prescription drugs overthecounter medicines and natural products This material is provided for educational purposes only and is not intended for medical advice diagnosis or treatment Data sources include Micromedex updated 2 Dec 2024 Cerner Multum updated 22 Dec 2024 ASHP updated 10 Dec 2024 and others diphenoxylate atropine Lomotil Uses Side Effects Dosage Diphenoxylateatropine also known as cophenotrope and sold under the brand name Lomotil among others is used to treat diarrhea 2 3 It is a fixeddose combination of the medications diphenoxylate as the hydrochloride an antidiarrheal and atropine as the sulfate an anticholinergic 1It is taken by mouth 2 Onset is typically within an hour 4 Diphenoxylate MedlinePlus Drug Information Diphenoxylate Alexander B Baer Christopher P Holstege in Encyclopedia of Toxicology Second Edition 2005 Mechanism of Toxicity Diphenoxylate is a narcoticlike substance that slows gastrointestinal motility and depresses the central nervous system producing coma and respiratory depression Anticholinergic effects secondary to the presence of atropine as an abuse deterrent can be seen Diphenoxylate comes as a tablet and solution liquid to take by mouth It is usually taken as needed up to 4 times a day Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part incracht you do not understand
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