ikba - IκΒα inhibits apoptosis at the outer lama permainan bola basket di tentukan oleh mitochondrial membrane IκBα Wikipedia The IKK Complex a Central Regulator of NFκB Activation Posttranslational Modifications of IκBα The State of the Art NFκB dictates the degradation pathway of IκBα PMC The NFκB Nuclear Factor kappa B transcription factor plays crucial roles in the regulation of numerous biological processes including development of the immune system inflammation and innate and adaptive immune responses Control over the immune cell functions of NFκB results from signaling th IκBα was the first IκB protein to be identified 21 and remains the most well characterized member of the family IκBα contains an Nterminal signal response region which is involved in inducer mediated degradation six ankyrin repeats that are important for interaction with NFκB family members and a C terminal PEST domain which regulates basal turnover of the protein Fig 2 2224 NFKBIA is a gene that encodes IKBA a protein that inhibits NFkappaB signaling pathway involved in inflammation Mutations in NFKBIA cause ectodermal dysplasia and immunodeficiency disorders NFκB IκB and IKK Integral Components of Immune System PubMed NFKBIA Gene GeneCards IKBA Protein IKBA Antibody IκB kinase Wikipedia The IκB kinase IkappaB kinase or IKK is an enzyme complex that is involved in propagating the cellular response to inflammation 1 specifically the regulation of lymphocytes The IκB kinase enzyme complex is part of the upstream NFκB signal transduction cascade The IκBα inhibitor of nuclear factor kappa B protein inactivates the NFκB transcription factor by masking the nuclear 18035 Ensembl ENSG00000100906 ENSMUSG00000021025 UniProt P25963 Q9Z1E3 RefSeq mRNA NM020529 NM010907 RefSeq protein NP065390 NP035037 Location UCSC Chr 14 354 354 Mb Chr 12 5554 5554 Mb PubMed search pokerasia99 Wikidata ViewEdit Human ViewEdit Mouse IκBα n uclear f actor of k appa light polypeptide gene enhancer in B cells i nhibitor a lpha NFKBIA is one member of a family The NFκBRel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins 13 Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasomemediated degradation that results in the release and nuclear translocation of active NFκB 37 IκBα is a key regulator of NFκB signaling pathway which is involved in inflammation immunity and cancer This review summarizes the molecular structure cellular localization and posttranslational modifications of IκBα such as phosphorylation ubiquitination and SUMOylation Introduction IκΒα functions as inhibitor of the inducible transcription factor NFκB by sequestering its subunits in the cytosol Baeuerle Baltimore 1996For the activation of NFκB IκBα is phosphorylated ubiquitinylated and degraded by the proteasome Hayden Ghosh 2008This allows the remaining dimeric subunits composed of relA p65 crel relB p50 or p52 to enter the IκBα Antibody Cell Signaling Technology Chen ZJ Parent L Maniatis T 1996 Sitespecific phosphorylation of IkBa by a novel ubiquitinationdependent protein kinase activity Cell 84853862 Google Scholar Cordier F Grubisha O Traincard F Véron M Delepierre M Agou F 2009 The zinc finger of NEMO is a functional ubiquitinbinding domain If the amount of the free protein is altered significantly this could have a detrimental effect on NFκB activation To test this hypothesis we introduced the longer halflife mutant IκBαΔC288 into ikba cells and measured if a significant amount of this mutant remains free compared with WT IκBα RelA was immunoprecipitated and IκBα kasino di arab saudi an overview ScienceDirect Topics
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