lipin - Lipin family proteinskey regulators in lipid glimepirid metabolism Lipin proteins and glycerolipid metabolism Roles at the ER LPIN1 Gene GeneCards LPIN1 Protein LPIN1 Antibody Lipins Lipinopathies and the Modulation of Cellular Lipid This puts lipin1 as a key integrator of hormonal signals to the liver in diabetic dyslipidemia This review summarizes the current understanding of the role that hepatic lipin1 plays in the synthesis storage and compartmentalization of glycerolipids and highlights the lipid metabolic consequences associated with dysregulated lipin expression Lipin proteins and glycerolipid metabolism roles at the ER The Lipin Family Mutations and Metabolism PMC Role of lipins in cardiovascular diseases PMC Dec 25 2024 LPIN1 is a gene that encodes a phosphatidate phosphatase enzyme involved in triglyceride synthesis and adipocyte differentiation It also acts as a transcriptional coactivator for PPARGC1APPARA and is associated with some metabolic disorders and lipodystrophy syndromes Lipin function has been evolutionarily conserved from a single ortholog in yeast to the mammalian family of three lipin proteinslipin1 lipin2 and lipin3 In mice and humans the levels of lipin activity are a determinant of TAG storage in diverse cell types and humans with deficiency in lipin1 or lipin2 have severe metabolic diseases A similar role has been proposed for lipin 1 during starvation in mammalian adipose tissue In mammalian liver starvation leads to lipin 1 upregulation There lipin activates genes of the fatty acid βoxidation pathway bolstering the capacity of the liver to process the increasing supply of free fatty acids derived from adipose tissue The meaning of LIPIN is lipid especially a complex lipid as a phosphatide or a cerebroside lipid especially a complex lipid as a phosphatide or a cerebroside See the full definition Lipin1 a Versatile Regulator of Lipid Homeostasis Is a Lipin2 is expressed at high levels in the liver kidney and brain and is the predominant lipin family member expressed in red blood cells bone marrow thymus and spleen although at levels that are much lower than those in liver Lipin2 expression like lipin1 is elevated in the liver during fasting 16 21 Nov 14 2023 Lipins are proteins that regulate lipid metabolism and inflammation and are involved in cardiovascular diseases CVDs This review summarizes the structures expression functions and modulation of lipins and their potential as therapeutic targets in CVDs Lipin Is a Central Regulator of Adipose Tissue Development The regulation of glycerolipid biosynthesis is critical for homeostasis of cellular lipid stores and membranes Here we review the role of lipin phosphatidic acid phosphatase enzymes in glycerolipid synthesis Lipin proteins are unique among glycerolipid biosynthetic enzymes in their ability to tran The coexpression of lipin 1 and lipin 3 from heterologous promoters that are not responsive to normal regulators of lipin gene expression led to increased lipin 1 protein and reduced lipin 3 protein levels This suggests that interaction of lipin 1 and lipin 3 influences their subcellular localization as well as protein concentration the Lipin function has been evolutionarily conserved from a single ortholog in yeast to the mammalian family of three lipin proteinslipin1 lipin2 and lipin3 In mice and humans the levels of lipin activity are a determinant togekup of TAG storage in diverse cell types and humans with deficiency in lipin1 or lipin2 have severe metabolic diseases The lipin protein family consisting of three members was first identified early this century In the last few years the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation and mutations in the corresponding genes cause lipodystrophy myoglobinuria and inflammatory disorders Here we review some of the progress toward elucidating the Lipin The bridge between hepatic glycerolipid biosynthesis Lipin proteins and metabolic homeostasis Journal of Lipid Lipins Lipinopathies and the Modulation of Cellular Lipid Lipin Family Proteins Structure Functions and Related Role of lipins in cardiovascular diseases Lipids in Health Lipins multifunctional lipid metabolism proteins PubMed Lipins Multifunctional Lipid Metabolism Proteins PMC Aug 3 2021 Lipins are enzymes that catalyze the dephosphorylation of PA to DAG and regulate lipid metabolism and gene expression This review covers the structure functions and regulatory mechanisms of lipins and their involvement in human diseases Dec 1 2010 Lipin is a protein that acts as a phosphatidate phosphatase and a transcription coactivator in glycerolipid biosynthesis Dysregulation of lipin expression affects lipid cargo availability membrane integrity and hormonal signaling and is linked to metabolic and cardiovascular diseases Regulation of Signaling and Metabolism by Lipinmediated Aug 21 2010 The lipin proteins are evolutionarily conserved proteins with roles in lipid metabolism and disease There are three lipin protein family members in mammals and one or two orthologs in plants invertebrates and singlecelled eukaryotes Studies in yeast and mouse led to the identification of two distinct molecular functions of lipin proteins Apr 23 2021 Lipin1 is a central regulator of lipid homeostasis acting either as an enzyme or as a coregulator of transcription In spite of its important functions it is only recently that several groups have highlighted its role in cancer Sep 4 2020 Phosphatidic acid PA is a glycerophospholipid intermediate in the triglyceride synthesis pathway that has incredibly important structural functions as a component of cell membranes and dynamic effects on intracellular and intercellular signaling pathways Although there are many pathways to synthesize and degrade PA a family of PA phosphohydrolases lipin family proteins that generate Lipin 1 is a coactivator of multiple transcription factors such as peroxisome proliferatoractivated receptor α and γ PPARα and PPARγ PPARγcoactivator 1α PGC1α hepatocyte nuclear factor 4α HNF4 and glucocorticoid receptor GR of which the effects of lipin 1 on PPARγ are unique because lipin 1 has a transcriptional The lipin family includes three members lipin1 lipin2 and lipin3 which exhibit tissuespecific expression indicating that they may have distinct roles in mediating disease To date most studies have focused on lipin1 whereas the roles of lipin2 and lipin3 are less understood Lipin The bridge between hepatic glycerolipid biosynthesis Lipin Definition Meaning MerriamWebster Medical The lipin gene family encodes the proteins lipin1 lipin2 and lipin3 The Lpin1 gene was first isolated from the fatty liver dystrophy fld mutant mouse strain 6 7 where lipin1 deficiency was identified as the cause of lipodystrophy insulin resistance peripheral neuropathy and neonatal fatty liver midclavicula in these animals 8
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