malat - Jan 9 2024 Kumar et al arti kode sekring mobil avanza show that the lncRNA Malat1 prevents gasdermin Dmediated pyroptosis induction in turn suppressing inflammatory cell death and mediating immune evasion and metastasis Molecular mechanisms of MALAT1 function In addition to its nuclear speckle localization MALAT1 has also been shown to be associated with chromatin Highthroughput chromatinRNA binding assays such as CHART and ChIRP 5354 have identified MALAT1 as a highly enriched RNA in the chromatin fraction where it has been shown to be associated with transcriptionally active genes Long noncoding RNA MALAT1 A versatile regulator in cancer MALAT1 Is a Key Regulator of EpithelialMesenchymal MDPI Oct 22 2018 Genetic analyses identify Malat1 as a metastasis suppressor To study the role of Malat1 in breast cancer instead of using the Malat1 gene deletion model showing upregulation of multiple Malat1 The long noncoding RNA Malat1 Its physiological and MALAT1 Expression Correlates with Prognosis in NonSmall Jan 1 2024 In addition there was no discernible difference between A549 cells transfected with the NC or siMALAT1 RAPA When injected into nude mice A549 cells transfected with siMALAT1 caused considerably smaller and lighter tumors in a mouse model 115 For MALAT1 to be considered a practical biomarker it should be applicable in a clinical Malic acid is an organic compound with the molecular formula HO2CCH OHCH2CO2H It is a metabolic intermediate in the citric acid cycle and contributes to the sour taste of many fruits such as apples grapes and rhubarb It was found that the high expression of MALAT1 in squamous cell lung carcinoma was closely related to the poor prognosis of cases In order to explore the mechanism of MALAT1 promoting lung carcinoma cell migration a study used siRNA to interfere with MALAT1 expression and found that cell motility decreased significantly Long noncoding RNA MALAT1 suppresses breast cancer metastasis May 8 2018 The deeper understanding of noncoding RNAs has recently changed the dogma of molecular biology assuming proteincoding genes as unique functional biological effectors while noncoding genes as junk material of doubtful significance In the last decade an exciting boom of experimental research has brought to light the pivotal biological functions of long noncoding RNAs lncRNAs MALAT1 a potential biomarker in cancer PMC Jul 3 2023 Magnesium is a mineral in several foods and many fruits contain malic acid The dietary supplement magnesium malate combines both This supplement can help with migraines and prevent magnesium As a result it is not a confounding that MALAT1 dysregulation may perhaps disrupt the proliferation and migration of FVMrelated cells which affect the DR pathogenesis In another study MALAT 1 expression was highly upregulated in STZinduced diabetic rats retina and dbdb mice MALAT1 ablation enhances DR in vivo Furthermore MALAT1 MALAT1 Is a Key Regulator of EpithelialMesenchymal PubMed MALAT1 a druggable long noncoding RNA for targeted anti MALAT1 as a Diagnostic and Therapeutic Target in Diabetes MALAT1 An Epigenetic Regulator of Inflammation in Diabetic MALAT1 Long NonCoding moror RNA Functional Implications PMC Jun 1 2024 MALAT1 is a long noncoding RNA that regulates cancer progression metastasis immunity and chemoresistance This article reviews the molecular mechanisms and clinical implications of MALAT1 in various types of cancer and its potential as a therapeutic target Jan 22 2016 2 Overview of MALAT1 MALAT1 is generally defined as a lncRNA that consists of 8000 nt and is coded by chromosome 11q13 MALAT1 transcripts are upregulated in a number of human carcinomas highly expressed in numerous cancer types including bladder cancer gallbladder carcinoma liver cancer melanoma colorectal cancer and gastric cancer and associated with metastasis Jan 4 2024 Metastasisassociated lung adenocarcinoma transcript1 MALAT1 is a long intergenic noncoding RNA lncRNA located on chr11q13 It is overexpressed in several cancers and controls gene expression through chromatin modification transcriptional regulation and posttranscriptional regulation Impo Magnesium Malate Uses Benefits Side Effects and Dosage MALAT1 is a large noncoding RNA that regulates metastasis and cell motility in lung cancer and other tissues It is also involved in temperaturedependent sex determination in turtles and alcoholinduced gene expression in brains MALAT1 Gene GeneCards MALAT1 RNA Gene MALAT1 Is a Key Regulator of EpithelialMesenchymal Apr 25 2018 The stability of the mature MALAT1 transcript differs across celltypes where MALAT has been reported to have a halflife of 9 hours in human cervical cells HeLa Tetoff 39 165 hours in Novel insight into MALAT1 in cancer Therapeutic targets and Abstract Simple Summary Metastasisassociated lung adenocarcinoma transcript1 MALAT1 is overexpressed in several cancers and exerts its effect by controlling gene expression and stimulating cell proliferation migration and metastasis and playing a dynamic role in mediating the epithelialtomesenchymal transition EMT which leads to the acquisition of stem celllike properties and Fang Z Zhang S Wang Y et al Long noncoding RNA MALAT1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins BMC Cancer 2016161706 doi 101186s128850162735x PMC free article Google Scholar 31 Hillen F Griffioen AW Schmidt LH Spieker T Koschmieder S Schäffers S Humberg J Jungen D Bulk E Hascher A Wittmer D Marra A et al The long noncoding MALAT1 RNA indicates a poor prognosis in nonsmall cell lung cancer and induces migration and tumor growth J Thorac Oncol 2011612198492 doi 101097JTO0b013e3182307eac Google Scholar LncRNA Malat1 suppresses pyroptosis and T cellmediated MALAT1 A key regulator in lung cancer pathogenesis and Jan 4 2024 MALAT1 is a long noncoding RNA that controls gene expression and stimulates cancer progression and metastasis by promoting epithelialtomesenchymal transition EMT This review summarizes the mechanisms pathways and targets of MALAT1 in cancer and explores its potential as a therapeutic target MALAT1 Wikipedia Dec 25 2024 MALAT1 is a long noncoding RNA that regulates gene expression and cell cycle in various tissues It is involved in cancer metastasis and cell migration and its expression is associated with tumor proliferation and bix progression Malic acid Wikipedia
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