mata2 - Dec 10 2024 CircMAT2B facilitates the xhamster3.com progression of head and neck squamous cell carcinoma via sponging miR4915p to trigger ASCT2mediated glutaminolysis Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B Apr 14 2022 Interrogating the methionine cycle dependency through a shortinterfering RNA screen identified the enzyme methionine adenosyltransferase 2A MAT2A as a critical vulnerability in these tumors Sequence comparison of MATa2 proteins Alignment of MATa2 May 1 2012 Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles MATa and MATα These sequences encode regulators of the two different haploid mating types and of the diploids formed by their conjugation MATa2 proteins from ATCC 42981 conserved a single MATAHMG box a class I member of the HMGbox superfamily of DNAbinding proteins Fig 4 coding a sequence spanning across the Ya and X Nov 11 2021 Mat2A has been identified as a promising target for novel cancer therapies with the discovery that it is synthetically lethal with the enzyme methylthioadenosine phosphorylase MTAP MAT2A inhibitor 1 is a methionine adenosyltransferase 2A MATA2 inhibitor with an IC50 less than l00 nM Mechanism of Action Protocol Human Mat2A Uses an Ordered Kinetic Mechanism and Is Oct 6 2024 MATA2 MATII SAMS2 Summary The protein encoded by this gene catalyzes the production of Sadenosylmethionine AdoMet from methionine and ATP AdoMet is the key methyl donor in cellular processes provided by RefSeq Jun 2011 Expression Ubiquitous expression in thyroid RPKM 2340 adrenal RPKM 1413 and 25 other tissues See more SCR7952 a highly selective MAT2A inhibitor demonstrates Oct 12 2016 The MAT2A gene encodes the catalytic subunit of extrahepatic methionine adenosyltransferase EC 2516 MAT II which catalyzes the biosynthesis of Sadenosylmethionine AdoMet or SAM from methionine and ATP summary by Mao et al 1998 AdoMet is the major methyl donor for many of the transmethylation reactions in the body MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of Sadenosylmethionine SAMe from Lmethionine and ATP MAT2A is expressed in extrahepatic tissues In liver MAT2A expression associates with growth dedifferentiation and cancer MATA2 SGD Saccharomyces Genome Database Official gene symbol which is typically a short form of the gene name according to HGNC Assigned HPA protein class es for the encoded protein s Number of proteincoding transcripts from the gene as defined by Ensembl What is the function of the MATa2 gene in yeast Sep 20 2024 Here we described a novel MAT2A inhibitor SCR7952 with potent and selective antitumor effects on MTAP deleted cancers in both in vitro and in vivo The cryoEM data indicated the high binding affinity kode surat 800 and the allosteric binding site of SCR7952 on MAT2A MAT2A Enzyme Human Recombinant MAT 2 Protein ProSpec 27430 Gene ResultMAT2B methionine adenosyltransferase 2 non METHIONINE ADENOSYLTRANSFERASE II ALPHA MAT2A OMIM MATA2 Phenotypes SGD Saccharomyces Genome Database The MATa2 gene in yeast plays a crucial role in the regulation of matingtype specific gene expression and chromosomal architecture It is part of a complex system that controls matingtype switching and gene repression in Saccharomyces cerevisiae MAT2A protein expression summary The Human Protein Atlas Dec 25 2024 MAT2A Methionine Adenosyltransferase 2A is a Protein Coding gene Diseases associated with MAT2A include Aortic Aneurysm Familial Thoracic 6 and Heritable Thoracic Aortic Disease Among its related pathways are methionine degradation and Metapathway biotransformation Phase I and II 4144 Gene ResultMAT2A methionine adenosyltransferase 2A P0CY12 UniProt Apr 26 2021 MAT2a is a methionine adenosyltransferase that synthesizes the essential metabolite S adenosylmethionine SAM from methionine and ATP Tumors bearing the codeletion of p16 and MTAP genes have been shown to be sensitive to MAT2a inhibition making it an attractive target for treatment of MTAPdeleted cancers Jul 7 2024 Clinical resource with information about MAT2A and available tests There are links to practice guidelines and authoritative resources like GeneReviews PubMed MedlinePlus PharmGKB and clinicaltrialsgov There are three genetic loci for mating type genes in Scerevisiae MAT is the expression locus that determines the mating type of the cell whereas HML containing HMLALPHA1 and HMLALPHA2 and HMR containing HMRA1 and HMRA2 represent silenced repositories of mating type information MAT2A inhibitor 1 MATA2 Inhibitor MedChemExpress Loss of MAT2A compromises methionine metabolism and MAT2A Gene GeneCards METK2 Protein METK2 Antibody MAT2A methionine adenosyltransferase 2A Homo sapiens human MAT2A methionine adenosyltransferase 2A NIH Genetic Testing FragmentBased Design of a Potent MAT2a Inhibitor and in Vivo Phenotype annotations for a gene are curated single mutant phenotypes that require an observable eg cell shape a qualifier eg abnormal a mutant type eg null strain background and a reference a2 is one of two genes encoded by the a mating type cassette in S cerevisiae The mating type of S cerevisiae is determined by the genetic composition of the MAT locus 3 4 2 Haploids of the a mating type express the genes a1 and a2 from the MAT locus while haploids of the alpha mating type express alpha1 and alpha2 from MAT 3 4 2 MAT2A Inhibition Blocks the Growth of MTAPDeleted Cancer Cells by Reducing PRMT5Dependent mRNA Splicing and Inducing DNA Damage Hsacirc0000337 promotes proliferation migration and invasion in glioma by competitively binding miRNA9425p and thus upregulates MAT2A MatingType Genes and burung kaka tua togel MAT Switching in Saccharomyces
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