neurotoksik - Neurotoxicity and Underlying Mechanisms of Endogenous rudaltogel Neurotoxins Neurotoxicity Types Clinical Manifestations Diagnosis and Treatment Neurotoxin an overview ScienceDirect Topics Neurotoxicity Wikipedia Illustration of typical multipolar neuron Exposure to neurotoxins in society is not new 19 as civilizations have been exposed to neurologically destructive compounds for thousands of years One notable example is the possible significant lead exposure during the Roman Empire resulting from the development of extensive plumbing networks and the habit of boiling vinegared wine in lead pans The nervous system is the communication and informationstorage system of the body In addition to coordinating functions that are commonly associated with the brain such as thinking the nervous system plays a major role in physiologic regulation Virtually all physiologic functions are influenced or controlled by the nervous system Other systems such as the circulatory and reproductive Neurotoxicity is a form of toxicity in which a biological chemical or physical agent produces an adverse effect on the structure or function of the central andor peripheral nervous system 1 It occurs when exposure to a substance specifically a neurotoxin or neurotoxicant alters the normal activity of the nervous system in such a way as to cause permanent or reversible damage to Mechanism of druginduced neurotoxicity and its management Neurotoxicants the Developing Brain and Mental Health PMC Neurotoxin Definition Examples Effects Britannica Neurotoxin Wikipedia Sources of major neurotoxicants and proposed physiological targets Exposure to the 3 classes of neurotoxicants discussed in this article lead outdoor particulate matter air pollution and endocrinedisrupting chemicals can occur through multiple avenues because the sources for these toxicants include broad environmental pollution from traffic agriculture industrial activities etc The human nervous system coordinates behavior in perceiving and responding to external stimuli it is responsible for mediating communication with the external environment and acero it coordinates the activities of all other organ systems and thus plays an essential role in maintaining metabolic balance The consequences of damage to the nervous system can be profound Massive injury can result in Introduction Defining the Problem of Neurotoxicity The metabolic process of MPTP Endogenous neurotoxins only attack one dopaminergic neuron at a time which is consistent with the slow progression of neurodegenerative diseases Many findings show that endogenous neurotoxins play an important role in the pathogenesis of neurodegenerative diseases neurotoxin substance that alters the structure or function of the nervous systemMore than 1000 chemicals are known to have neurotoxic effects in animalsThe substances include a wide range of natural and humanmade chemical compounds from snake venom and pesticides to ethyl alcohol heroin and cocaine Characteristics Biologic Basis of Neurotoxicity Environmental Neurotoxicology NCBI Natural biological agents or drugs with high target specificity and neurotoxic potency are found in microbes insects and other organisms for example vitamin A diphtheria toxin apamin palytoxin and scorpion toxin Pereira et al 2017Heavy metals and synthetic chemicals having neurotoxic potential are lead mercury arsenic pesticides acrylamide pyrolysis products pyridinethione Neurotoxins are compounds that are toxic or potentially toxic to the nervous system Capable of mimicking neurologic syndromes neurotoxins can be classified into 3 main categories 1 drugs prescription over the counter and illicit 2 chemicals industrial household and abused agents 3 environmental biologic agents and naturally occurring chemicals Neurotoxicity is a term that refers to the condition in which the nervous system is exposed to dangerous substances neurotoxicants either naturally occurring or created impairing the nervous systems normal function Few of these neurotoxins act directly on neural cells whereas others impair metabolic processes heavily reliant on the neurological system Neurotoxicity can arti angka 2222 occur as a side
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