podn - PODN podocan human Gene ID 127435 spartaban updated on 17Jun2024 Summary The protein encoded by this gene is a member of the small leucinerich repeat protein family and contains an amino terminal CX3CXCX7C cysteinerich cluster followed by a leucinerich repeat domain Studies suggest that this protein could function to inhibit smooth muscle PODN Gene GeneCards PODN Protein PODN Antibody The gov means its official Federal government websites often end in gov or mil Before sharing sensitive information make sure youre on a federal government site 127435 Gene ResultPODN podocan human National Center for PODN podocan NIH Genetic Testing Registry GTR NCBI Podocan unraveled Understanding its role in tumor proliferation and The discovery of podocan over 20 years ago has led to significant insights into its role in various biological processes In 2003 Michael D Ross discovered podocan PODN a new member of the small leucinerich repeat SLR protein family while studying podocytes infected with HIVassociated nephropathy HIVAN 1He found that podocan is overexpressed in sclerotic glomerular lesions Entry 608661 PODOCAN PODN OMIM PODN podocan Homo sapiens human Gene NCBI Go to Variation Viewer for PODN variants Summary The protein encoded by this gene is a member of the small leucinerich repeat protein family and contains an amino terminal CX3CXCX7C cysteinerich cluster followed by a leucinerich repeat domain Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and PODN had an important role of profound clinical significance For example studies by YiSun et al have shown that miR31805p reduces the expression of PODN and leads to cyclindependent kinase 2 cdk2mediated proliferation of HBSMCs in human bladder smooth muscle suku sentinel cells Podocan encoded by PODN can be found in a variety of cells PODN protein expression summary The Human Protein Atlas PODN was regarded as a potential biomarker for the diagnosis and prognosis of osteosarcoma ACTA2 COL6A1 FAP OLFML2B and COL6A3 can be used as potential prognostic indicators for osteosarcoma Osteosarcoma was the most common primary bone malignancy in children and adolescents It was imperative to identify effective prognostic biomarkers PODN is a prognostic biomarker and correlated with immune infiltrates PODN was regarded as a potential biomarker for the diagnosis and prognosis of osteosarcoma ACTA2 COL6A1 FAP OLFML2B and COL6A3 can be used as potential prognostic indicators for osteosarcoma PODN is a prognostic biomarker and correlated with immune infiltrates in osteosarcoma PODN is a prognostic biomarker and correlated with immune PubMed PODN is a prognostic marker in Bladder urothelial carcinoma Kidney renal papillary cell carcinoma Liver hepatocellular carcinoma Pancreatic adenocarcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched group enriched cancer enhanced low cancer specificity and not detected PODN Podocan is a Protein Coding gene Diseases associated with PODN include Prostate Cancer Gene Ontology GO annotations related to this gene include collagen binding An important paralog of this gene is PODNL1 PODN is a prognostic biomarker and correlated with immune infiltrates Mouse and human PODN proteins share greater than 91 amino acid identity Podocan is highly homologous to members of the small leucinerich repeat protein SLRP family which are proteoglycans that regulate and maintain extracellular matrix collagen fibrils Podocan contains an Nterminal cysteinerich cluster pattern kode produksi dan expired and an acidic Cterminal
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