rkip - Oct 17 2022 RAFkinase inhibitor protein kode kode negara RKIP is an endogenous tumour suppressor protein that affects tumour cell survival proliferation and metastasis RKIP might serve as an early tumour biomarker since it exhibits significantly different expression levels in various cancer histologies and it is often lost during metastatic progression RKIP and its finance partners make investments into intellectual property assets where insurance is available as a backstop Litigation Finance and Judgment Preservation RKIP and its finance partners provide asset based funding to support patent litigation pre and postoutcomes Jan 1 2020 Furthermore RKIP is a favorable therapeutic target in a variety of cancers Novel treatment strategies that incorporate conventional drugs in combination with new agents that promote RKIP expression show alleviation of cancer aggressiveness and can resensitize resistant tumors toward chemotherapy and immunemediated cytotoxicity Home RKIP Overexpression of RKIP and its crosstalk with several Raf kinase inhibitory protein a signal transduction Nature RKIP phosphorylation at Serine 153 pS153 by PKC results in RKIP release from Raf1 and binding to GRK2 an endogenous inhibitor of GPCR activation 68687 Binding of pS153RKIP to GRK2 is causing the dissociation of GRK2 from GPCR allowing GPCR activation and phosphorylation of downstream targets including Raf1 Raf kinase inhibitor protein RKIP in cancer PubMed RKIP in human diseases and its potential as a prognostic I INTRODUCTION Raf kinase inhibitory protein RKIP is a homeostatic regulator of the mammalian kinome and inhibits a number of key signaling networks including RafMAP kinase βadrenergic signaling and NFκB signaling 13 As expected for a protein involved in so many pathways modulating RKIP function results in a wide range of physiological effects Apr 1 2008 Cells have a multitude of controls to maintain their integrity and prevent random switching from one biological state to another Raf Kinase Inhibitory Protein RKIP a member of the Current Status of Raf Kinase Inhibitor Protein RKIP in Lung May 5 2017 Low RKIP expression is found in many cancers such as bladder breast gastric nonsmall cell lung prostate and other cancers 20 565758In metastatic melanoma downregulation of both RKIP and phosphorylated RKIP has been noted while low RKIP and highphosphorylated RKIP expression may be indicative of nonmetastatic melanoma RKIP A Key Regulator in Tumor Metastasis Initiation and RKIP has been identified as an important protein in various cancer types several of which have been described above In the majority of different types of cancers RKIP exhibits low expression levels and RKIP is often absent in metastasis RKIP loss has been suggested to result from the hypermethylation of its promoter Of note RKIP activationinactivation can indirectly interfere with upstream activators of Raf1 such as Gprotein coupled receptors GPCR In fact RKIP phosphorylation by protein kinase C PKC not only releases and activates Raf1 but also associates RKIP with a GPCR inhibitor namely GRK2 The biological complexity of RKIP signaling in human cancers Dec 11 2022 Vu et al examined the role of RKIP on immune response genes in breast cancer They showed that knocking down RKIP increased the expression of enriched genes that are vital for type 1 and 2 interferonmediated inflammatory responses in breast cancer cells Thus they provided evidence empada that RKIP is indeed an immune modulator in breast cancer May 10 2019 Raf kinase inhibitory protein RKIP is an important modulator of relevant intracellular signaling pathways including those controlled by EGFR such as MAPK It has been reported that it has metastasis suppressor activity and a prognostic role in several solid tumors including lung cancer RKIP inhibits NFκB in cancer cells by regulating upstream RKIP expression has been shown to be downregulated in metastatic tissues compared with nonmetastatic tissue in multiple cancers suggesting that loss of RKIP metastasis suppressor activity is a broad mechanism leading to metastasis Additionally loss of RKIP has been shown to impact therapy through conferring radioresistance and chemoresistance RKIP Structure Drives Its Function A ThreeState Model for The Raf kinase inhibitor protein RKIP is a kinase inhibitor protein that regulates many signaling pathways within the cell 1 RKIP is a member of the phosphatidylethanolaminebinding protein family and has displayed disruptive regulation on the Raf1MEK12 ERK12 and NFkappaB signalling pathways by interaction with the Raf1 kinase Raf kinase inhibitor protein Wikipedia In 2019 Dr Stavroula Baritaki organised the second RKIP workshop in Crete during which we discovered the necessity of creating an international consortium to deal with the increasing RKIP intracellular network complexity In 2023 Prof Massimo Libra brought us all together in beautiful Catania Sicily to attend the first RKIPYY1 conference RKIP A Pivotal Gene Product in the Pathogenesis of Cancer RKIP was first identified as an inhibitor of the RafMEKERK signaling pathway RKIP was also found to play an important role in the NFΚB pathway Genetic and biochemical studies demonstrated that RKIP functioned as a scaffold protein facilitating the phosphorylation of IκB by upstream kinases RKIP Management LLC Intellectual Property Financing and RKIP Pleiotropic Activities in Cancer and Inflammatory Understanding Mechanisms of RKIP Regulation to Improve the Dec 13 2021 Several gene products play pivotal roles in the induction of inflammation and the progression of cancer The Raf kinase inhibitory protein RKIP is a cytosolic protein that exerts pleiotropic activities in such conditions and thus regulates oncogenesis and immunemediated diseases through its deregulation Herein we review the general properties of RKIP including its i molecular Biological and therapeutic implications of RKIP in Aug 24 2018 RKIP exerts antimetastatic and proapoptotic properties in cancer cells via modulation of signaling pathways and gene products involved RAFkinase inhibitor protein RKIP is a wellestablished tumor suppressor that is frequently downregulated in a plethora of solid and hematological malignancies Sep 25 2015 RKIP is posttranscriptionally controlled by miR27a and downregulation of RKIP impairs chemotherapeutic druginduced apoptotic responses in cancer cells 25 Knockdown of RKIP resulted in an Understanding Mechanisms of RKIP Regulation to Improve the RKIP A Key Regulator in Tumor Metastasis Initiation and RKIP Pleiotropic Activities in Cancer and Inflammatory MDPI Oct 31 2023 The association between RKIP expression and clinicalpathological and molecular features is summarized in Suppl Table S1The Kaplan Meier analysis demonstrated that RKIPnegative patients tend to have a poor overall survival in five years the overall survival of RKIPnegative patients was only 509 compared to the RKIPpositive patients who showed a fiveyear survival rate universitas mikroskil of 702 p 0
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