shokat - Kevan Shokat PhD Biomedical Sciences Graduate wilhelmina Program Kevan Shokat UCSF Profiles Kevan Shokat Research UC Berkeley Browse the latest publications from the Shokat Lab at UCSF led by Kevan Shokat a pioneer in chemical biology and protein kinase inhibition Find research on PKC COX2 IFITM p53 Gαs KRas mTOR and more Kevan Shokat Chemical Biologist and Cancer Researcher Learn how Dr Shokat and his team discovered a hidden pocket in KRAS a notorious cancercausing protein and developed the first FDAapproved drug to target it Read about his journey challenges and achievements in cancer research and chemistry Research Kevan M Shokat PhD Drugging the Elusive KRAS The AACR Science world honors Kevan Shokat for highimpact cancer Jul 19 2024 Email KevanShokat ucsf edu 600 16th Street MC 2280 Genentech Hall Room N512D San Francisco CA 941582280 Phone 415 5140472 Administrative Assistant Kevan M Shokat American Academy of Arts and Sciences Kevan Shokat studies two of the most critical types of regulatory enzymes in the body kinases and GTPases both of which are key to directing cell activity Shokat develops novel chemical tools to decipher how these enzymes interact with other proteins and contribute to cell signaling networks under both normal and diseased conditions Kevan Shokat Wikipedia The Shokat lab at UCSF uses chemical genetics to study and target signaling proteins such as kinases GTPases and RNA helicases in human diseases Learn about their projects on KRas mTOR LRRK2 DDX3 and more Kevan SHOKAT UCSF University of California San Francisco KRasG12C inhibitors allosterically control GTP affinity Feb 17 2023 Kevan Shokat PhD a UCSF professor of cellular and molecular pharmacology has developed a successful approach to drugging a protein produced by the mutated KRAS gene which drives 30 of human cancers He has received the NAS Award for Scientific Discovery and the Sjöberg Prize for his pioneering breakthroughs in chemical biology to advance cancer therapy Kevan Shokat College of Chemistry Kevan Shokat is a professor of chemistry at UC Berkeley and a researcher at UCSF He studies proteinlipid kinases GTPases and RNA helicases using synthetic organic chemistry protein engineering and pharmacology Kevan Shokat Kevan M Shokat PhD UCSF Helen Diller Family Comprehensive Kevan Shokat Bifunktionelle Liganden wurden synthetisiert die die Assoziation von KRas und ImmunophilinProteinen darunter FKBP12 und Cyclophilin A induzieren The Shokat lab studies and targets signaling proteins using chemical genetics a technique that combines small molecules and genetics The lab focuses on kinases GTPases and RNA helicases and their roles in human diseases such as cancer and Parkinsons Shokat Lab Science World Honors Kevan Shokat for HighImpact Cancer Nov 2 2023 Learn about the life and work of Kevan Shokat a leading chemical geneticist who studies signaling batu candi proteins and develops targeted therapies for cancer He shares his academic family tree his research agenda and his role as a mentor and entrepreneur Sep 21 2017 Chemical biologist Kevan Shokat brings a unique perspective to the development of molecularly targeted therapies He began his research career as an organic chemist only later turning to biology He believes that this hybrid training enables him to think chemically but with a deep enough understanding of biology to know what to focus on Publications Nov 20 2013 Here Shokat and colleagues report the development of small molecules that irreversibly bind to the common G12C mutant of KRas but not to the wildtype protein Crystallographic studies reveal Kevan M Shokat PhD Investigator Profile 2005Present HHMI Oct 3 2024 Kevan M Shokat is Professor and Chair of Cellular and Molecular Pharmacology at the University of California San Francisco Professor of Chemistry at the University of California Berkeley and an Investigator of the Howard Hughes Medical Institute Shokat has developed chemical methods to decipher the role of protein kinases Kevan Michael Shokat born August 26 1964 1 is an American chemical biologist He is a Professor and chair in the Department of Cellular and Molecular Pharmacology at University of California San Francisco a professor in the Department of Chemistry at University of California Berkeley and an Investigator with the Howard Hughes Medical Institute Thinking Chemically to Discover New Targeted Cancer Drugs Zhulyn O Rosenblatt HD Shokat L Dai S KuzuogluÖztürk D Zhang Z Ruggero D Shokat KM Barna M mTOR inhibition reprograms cellular proteostasis by regulating eIF3Dmediated selective mRNA translation and promotes cell phenotype switching Kevan Shokat PhD UCSF Macromolecular Structure Group Kevan Shokats profile publications research topics and coauthors Wassarman DR Bankapalli K Pallanck LJ Shokat KM Tissuerestricted inhibition of mTOR using chemical genetics Proc Natl Acad Sci U S A 2022 09 20 11938e2204083119 View on PubMed Zhang Z Morstein J Ecker AK Guiley KZ Shokat KM Chemoselective Covalent Modification of KRasG12R with a Small Molecule Electrophile Kevan Shokat Kevan Shokat Contact kevanshokatucsfedu 415 5140472 Shokat Lab Lab address 600 16th Street Genentech Hall Room N514 San Francisco CA 94158 The Shokat lab uses chemical genetics to study and target signaling proteins with the aim of finding new ways to treat human diseases Publications HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma Feb 20 2023 The pace of KRAS drug discovery is moving so fast now that our assumptions about what seems possible are changing monthbymonth Kevan Shokat In a statement the NAS called Shokat a pioneer of modern chemical biology using innovative approaches to develop powerful molecular tools to advance basic simomtok knowledge and combat devastating
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