taci - Transmembrane Activator and CAML Interactor TACI rp800.000 Another Potential TACI an enigmatic BAFFAPRIL receptor with new unappreciated PubMed The discovery of TACI mutations associated with common variable immunodeficiency CVID in humans not only reinforces its important role for humoral responses but also suggests a more complex role than first anticipated from knockout animals TACI is emerging as an unusual TNF receptorlike molecule with a sophisticated mode of action TACI deficiency a complex system out of balance TACI lacks a TIR domain yet triggered CSR via the DNAediting enzyme AID by activating NFκB through a Tolllike receptor TLRlike MyD88IRAK1IRAK4TRAF6TAK1 pathway TACIinduced CSR was Ligandindependent oligomerization of TACI is controlled by the Effect of TACI signaling on humoral immunity and autoimmune diseases TACI is a transmembrane protein that binds to APRIL BAFF and CAML and regulates B cell functions It is involved in humoral immunity isotype switching and B cell homeostasis and mutations can cause immunodeficiency The TACI protein is found on the surface of immune system cells called B cells These specialized white blood cells help protect the body against infection from foreign invaders such as bacteria and viruses When B cells mature they produce special proteins called antibodies also known as immunoglobulins Transmembrane activator and calciummodulating cyclophilin ligand interactor TACI is one of the receptors of B cell activating factor of the tumor necrosis factor family BAFF and a proliferationinducing ligand APRIL TACI is a regulator in the immune responses TACI inhibits B cell expansion TACI is a TNF receptor that regulates jarak adalah Bcell function and antibody production Mutations in TACI are associated with common variable immunodeficiency CVID and autoimmunity Learn about TACI structure expression signaling and network in this review article BAFFR and TACIdependent upregulation of MHC class II in B cells A Purified wildtype and TACI B splenocytes were stimulated plus or minus crosslinked APRIL in the presence of IL4 and IL6 and surface expression of MHC class II was monitored by FACS B Experiment was performed as in panel A with B cells of the indicated Evaluating TACI expression in the brain Single cell analysis from the Human Protein Atlas 3132 showed enriched expression TNFRSF13B the gene that codes for TACI in plasma cells and B cells Ligandreceptor interactions in the BAFFAPRIL and BAFFRBCMATACI system BAFF and APRIL are first synthetized as type II transmembrane proteins mainly in myeloid and stromal cells and processed by furin protease into trimeric soluble cytokines BAFF 3mer and APRIL 3mer Twenty soluble BAFF 3mers can be further oligomerized into a viruslike particle called BAFF 60mer BAFFR BCMA Transmembrane activator and CAML interactor Wikipedia TACI unlike BAFFR is solely activated by oligomeric BAFF and APRIL TACI is a TNF receptor that binds BAFF and APRIL and regulates B cell survival differentiation and antibody production The transmembrane domain of TACI forms trimers and dimers that mediate liganddependent and independent signaling which are affected by CVIDassociated mutations AntiTACI single and dualtargeting CAR T cells overcome BCMA antigen TNFRSF13B gene MedlinePlus The transmembrane activator mukhabaroh TACI triggers immunoglobulin class
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