talidomid - thalidomide compound in medicine initially used kampoeng vietnam as a sedative and an antiemetic until the discovery that it caused severe fetal malformations Thalidomide was developed in West Germany in the mid1950s and was found to induce drowsiness and sleep The drug appeared to be unusually safe with few side effects and little or no toxicity even at high doses Thalidomide MedlinePlus Drug Information Thalidomide Uses Side Effects Warnings Drugscom Thalidomide the tragedy of birth defects and the effective PubMed Thalidomide scandal Wikipedia Thalidomide Medical Compound Teratogen History Britannica Thalidomide Wikipedia Thalidomide αNphthalimido glutarimide was first synthesized in 1953 by Ciba a Swiss pharmaceutical firm and then in 1954 by Kunz a chemist at Chemie Grünenthal a German pharmaceutical company12 On October 1 1957 Chemie Grünenthal introduced the drug into the market as a sedative134 Thalidomide lacked the typical addictive properties of barbiturates and produced a natural Dr Frances Kelsey is awarded the Presidents Award for Distinguished Federal Civilian Service from President John F Kennedy in 1962 An estimated 10000 infants were affected worldwide with more uncounted stillborn or miscarried pregnancies Franks et al 2004A lasting impact of these tragic events has been in the positive change in the drug regulation process Thalidomide was first developed as a tranquilizer by Swiss pharmaceutical company Ciba in 1953 In 1954 Ciba abandoned the product and it was acquired by German pharmaceutical company Chemie Grünenthal 4 The company had been established by Hermann Wirtz Sr a Nazi Party member after World War II as a subsidiary of the familys Mäurer Wirtz company Structure of CRBNbinding drugs A ThalidomideB LenalidomideC PomalidomideD CC885E CC122F CC220G dBET1 composed of JQ1 a BRD4 inhibitor and thalidomideH UridineIn 1965 an Israeli physician found that thalidomide is effective for treating erythema nodosum leprosum a specific type of leprosy resulting in painful skin lesions 4 During the 1980s and early 1990s Thalidomide side kekasih gelapku effects Get emergency medical help if you have signs of an allergic reaction hives difficult breathing swelling in your face or throat or a severe skin reaction fever sore throat burning eyes skin pain red or purple skin rash with blistering and peeling Seek medical treatment if you have a serious drug reaction that can affect many parts of your body Thalidomide is used along with dexamethasone to treat multiple myeloma in people who have been recently found to have this disease It is also used alone or with other medications to treat and prevent skin symptoms of erythema nodosum leprosum ENL episodes of skin sores fever and nerve damage that occur in people with Hansens disease leprosy Thalidomide sold under the brand names Contergan and Thalomid among others is an oral medication used to treat a number of cancers eg multiple myeloma graftversushost disease and many skin disorders eg complications of leprosy such as skin lesions 6 7 Thalidomide has been used to treat conditions associated with HIV aphthous ulcers HIVassociated wasting syndrome The Rise Fall and Subsequent Triumph of Thalidomide Lessons Learned Thalidomide is a medication used to manage and treat advanced leprosy and multiple myeloma and various other solid and hematologic malignancies It is in the immunomodulatory class of medications This activity reviews the indication action and contraindications for thalidomide as a valuable agent in the treatment of leprosy multiple myeloma and other malignancies when applicable This Thalidomide Tragic Past and Promising Future Thalidomide was a widely used drug in the late 1950s and early 1960s for the treatment of nausea in pregnant women It became apparent in the 1960s that thalidomide treatment resulted in severe birth defects in thousands of children Though the use of thalidomide was banned in most countries at that Thalidomide StatPearls NCBI Bookshelf Molecular mechanisms of thalidomide rtp live slot airbet88 and its derivatives PMC
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